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Thus, central to MyD88 function is the ability ofMyeloid differentiation primary response protein 88 (MyD88) is classically known as an adaptor, linking TLR and IL-1R to downstream signaling pathways in the innate immune system. 00 ๐Ÿ’ต ๐–๐ˆ๐“๐‡๐ƒ๐‘๐€๐– ๐‘๐Œ 2061. Background A universal adaptor protein, MyD88, orchestrates the innate immune response by propagating signals from toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R). Because Kupffer cells are the major source of proinflammatory cytokines, studies were conducted to discern IL-6 production in mouse Kupffer cells following hypoxia.